A Functional Polymorphism Downstream of Vitamin A Regulator Gene CYP26B1 Is Associated with Hand Osteoarthritis.

doi:10.3390/ijms24033021

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Article

A Functional Polymorphism Downstream of Vitamin A Regulator Gene CYP26B1 Is Associated with Hand Osteoarthritis.

International journal of molecular sciences - 3 Feb 2023

Khosasih Vivia, Liu Kai-Ming, Huang Chung-Ming, Liou Lieh-Bang, Hsieh Ming-Shium, Lee Chian-Her, Tsai Chang-Youh, Kuo San-Yuan, Hwa Su-Yang, Yu Chia-Li, Chang Chih-Hao, Lin Cheng-Jyh, Hsieh Song-Chou, Cheng Chun-Ying, Chen Wei-Ming, Chen Liang-Kuang, Chuang Hui-Ping, Chen Ying-Ting, Tsai Pei-Chun, Lu Liang-Suei, H'ng Weng-Siong, Zhang Yanfei, Chen Hsiang-Cheng, Chen Chien-Hsiun, Lee Ming Ta Michael, Wu Jer-Yuarn

Abstract excerpt

While genetic analyses have revealed ~100 risk loci associated with osteoarthritis (OA), only eight have been linked to hand OA. Besides, these studies were performed in predominantly European and Caucasian ancestries. Here, we conducted a genome-wide association study in the Han Chinese population to identify genetic variations associated with the disease. We recruited a total of 1136 individuals (n = 420 hand...

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PMID: 36769350
DOI: 10.3390/ijms24033021
PMCID: PMC9918232

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