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Article

Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure.

Diabetologia - 1 Jul 2014

Muller Yunhua L, Piaggi Paolo, Hoffman Duncan, Huang Ke, Gene Brittany, Kobes Sayuko, Thearle Marie S, Knowler William C, Hanson Robert L, Baier Leslie J, Bogardus Clifton

Abstract excerpt

AIMS/HYPOTHESIS: Glucokinase (GCK) plays a role in glucose metabolism and glucose-stimulated insulin secretion. Rare mutations in GCK cause MODY. We investigated whether common variation (minor allele frequency ≥0.01) in GCK is associated with metabolic traits and type 2 diabetes. METHODS: Four exonic single-nucleotide polymorphisms (SNPs) and three SNPs predicted to cause loss of promoter function were...

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Source

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Identifiers

PMID: 24728127
DOI: 10.1007/s00125-014-3234-8
PMCID: PMC4052004

Genes

GCK

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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