Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.

PloS one - 1 Jan 2022

Chen Guanjie, Shriner Daniel, Zhang Jianhua, Zhou Jie, Adikaram Poorni, Doumatey Ayo P, Bentley Amy R, Adeyemo Adebowale, Rotimi Charles N

Abstract excerpt

Impaired glucose tolerance is a major risk factor for type 2 diabetes (T2D) and several cardiometabolic disorders. To identify genetic loci underlying fasting glucose levels, we conducted an analysis of 9,232 individuals of European ancestry who at enrollment were either nondiabetic or had untreated type 2 diabetes. Multivariable linear mixed models were used to test for associations between fasting glucose and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptor Proteins, Signal Transducing
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diabetes Mellitus, Type 2

Share to Fasting

Share to Glucose

Share to Glucose-6-Phosphatase

Share to Polymorphism, Single Nucleotide

Share to Zinc Transporter 8

Source

Open in PubMed Open full text

Identifiers

PMID: 35657990
DOI: 10.1371/journal.pone.0269378
PMCID: PMC9165855

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Additive genetic effect of GCKR, G6PC2, and SLC30A8 variants on fasting glucose levels and risk of type 2 diabetes.PMID 35657990Read ↗

A genetic variant of G6PC2 is associated with type 2 diabetes and fasting plasma glucose level in the Chinese population.Semantic proximity Read ↗

Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels.Semantic proximity Read ↗

The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population.Semantic proximity Read ↗

Effects of genetic variants previously associated with fasting glucose and insulin in the Diabetes Prevention Program.Semantic proximity Read ↗

Large scale meta-analyses of fasting plasma glucose raising variants in GCK, GCKR, MTNR1B and G6PC2 and their impacts on type 2 diabetes mellitus risk.Semantic proximity Read ↗

Patients with Type 2 Diabetes and a<i>GCK</i>variant are still at risk for T2D-related secondary complicationsSemantic proximity Read ↗

Underestimated risk of secondary complications in pathogenic and glucose-elevating GCK variant carriers with type 2 diabetesSemantic proximity Read ↗

Genetic discovery and translational decision support from exome sequencing of 20,791 type 2 diabetes cases and 24,440 controls from five ancestriesSemantic proximity Read ↗

Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program.Semantic proximity Read ↗

Heritability and genome-wide association analyses of fasting plasma glucose in Chinese adult twins.Semantic proximity Read ↗

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.Semantic proximity Read ↗

Effect of sequence variants on variance in glucose levels predicts type 2 diabetes risk and accounts for heritability.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.