Article
Unique molecular alteration patterns in von Hippel-Lindau (VHL) gene in a cohort of sporadic renal cell carcinoma patients from Pakistan.
Mutation research - 1 Jan 2000
Khaliq Shagufta, Ajaz Sadia, Firasat Sadaf, Shahid Saba, Hasan Asad Shahzad, Sultan Gauhar, Mohsin Rehan, Hashmi Altaf, Mubarak Muhammed, Naqvi Syed Ali Anwar, Rizvi Syed Adib-Ul-Hasan, Mehdi Syed Qasim, Abid Aiysha
Abstract excerpt
BACKGROUND: Renal cell carcinoma (RCC) is the most frequent form of kidney cancer in adults. Somatic mutations that inactivate the von Hippel-Lindau (VHL) gene are the most common cause of RCC. The frequencies of molecular changes in the VHL gene in RCCs vary among different populations. So far, a single chromosomal-based study has been reported from a South Asian population. This report presents, for the first...
Topics
- Adult
- Age Factors
- Carcinoma, Renal Cell
- Cohort Studies
- DNA Methylation
- Female
- Humans
- Kidney Neoplasms
- Male
- Mutation
- Pakistan
- Promoter Regions, Genetic
- Von Hippel-Lindau Tumor Suppressor Protein