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Article

CpG methylation profiling in VHL related and VHL unrelated renal cell carcinoma

3 Jun 2009

Abstract excerpt

BACKGROUND: Renal cell carcinoma (RCC) is histopathologically heterogeneous with clear cell and papillary the most common subtypes. The most frequent molecular abnormality in clear cell RCC is VHL inactivation but promoter methylation of tumour suppressor genes is common in both subtypes of RCC. To investigate whether RCC CpG methylation status was influenced by histopathology and VHL status we performed...

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PMID: 19493342
DOI: 10.1186/1476-4598-8-31

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