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Article

Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

The Journal of experimental medicine - 2 Jul 2012

Boulard Olivier, Kirchberger Stefanie, Royston Daniel J, Maloy Kevin J, Powrie Fiona M

Abstract excerpt

Chronic inflammation of the intestine has been associated with an elevated risk of developing colorectal cancer. Recent association studies have highlighted the role of genetic predisposition in the etiology of colitis and started to unravel its complexity. However, the genetic factors influencing the progression from colon inflammation to tumorigenesis are not known. We report the identification of a genetic...

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Identifiers

PMID: 22734048
DOI: 10.1084/jem.20120239
PMCID: PMC3405508

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