Article
CCDC22 deficiency in humans blunts activation of proinflammatory NF-κB signaling.
The Journal of clinical investigation - 1 May 2013
Starokadomskyy Petro, Gluck Nathan, Li Haiying, Chen Baozhi, Wallis Mathew, Maine Gabriel N, Mao Xicheng, Zaidi Iram W, Hein Marco Y, McDonald Fiona J, Lenzner Steffen, Zecha Agnes, Ropers Hans-Hilger, Kuss Andreas W, McGaughran Julie, Gecz Jozef, Burstein Ezra
Abstract excerpt
NF-κB is a master regulator of inflammation and has been implicated in the pathogenesis of immune disorders and cancer. Its regulation involves a variety of steps, including the controlled degradation of inhibitory IκB proteins. In addition, the inactivation of DNA-bound NF-κB is essential for its regulation. This step requires a factor known as copper metabolism Murr1 domain-containing 1 (COMMD1), the prototype...
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