Article
Alternative Sampling Strategies for Cytochrome P450 Phenotyping.
Clinical pharmacokinetics - 1 Feb 2016
De Kesel Pieter M M, Lambert Willy E, Stove Christophe P
Abstract excerpt
Interindividual variability in the expression and function of drug metabolizing cytochrome P (CYP) 450 enzymes, determined by a combination of genetic, non-genetic and environmental parameters, is a major source of variable drug response. Phenotyping by administration of a selective enzyme substrate, followed by the determination of a specific phenotyping metric, is an appropriate approach to assess the in vivo...
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