Article
HOXB13 G84E-related familial prostate cancers: a clinical, histologic, and molecular survey.
The American journal of surgical pathology - 1 May 2014
Smith Steven C, Palanisamy Nallasivam, Zuhlke Kimberly A, Johnson Anna M, Siddiqui Javed, Chinnaiyan Arul M, Kunju Lakshmi P, Cooney Kathleen A, Tomlins Scott A
Abstract excerpt
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer. The histomorphologic and molecular features of cancers arising in such carriers have not been studied. Here, we reviewed prostatectomy specimens from 23 HOXB13 G84E mutation...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.