Article
Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci.
JCI insight - 22 Feb 2022
Fontugne Jacqueline, Cai Peter Y, Alnajar Hussein, Bhinder Bhavneet, Park Kyung, Ye Huihui, Beg Shaham, Sailer Verena, Siddiqui Javed, Blattner-Johnson Mirjam, Croyle Jaclyn A, Noorzad Zohal, Calagua Carla, MacDonald Theresa Y, Axcrona Ulrika, Bogaard Mari, Axcrona Karol, Scherr Douglas S, Sanda Martin G, Johannessen Bjarne, Chinnaiyan Arul M, Elemento Olivier, Skotheim Rolf I, Rubin Mark A, Barbieri Christopher E, Mosquera Juan Miguel
Abstract excerpt
BACKGROUNDProstate cancer is multifocal with distinct molecular subtypes. The utility of genomic subtyping has been challenged due to inter- and intrafocal heterogeneity. We sought to characterize the subtype-defining molecular alterations of primary prostate cancer across all tumor foci within radical prostatectomy (RP) specimens and determine the prevalence of collision tumors.METHODSFrom the Early Detection...
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