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Article

Characterization of 1577 primary prostate cancers reveals novel biological and clinicopathologic insights into molecular subtypes.

European urology - 1 Oct 2015

Tomlins Scott A, Alshalalfa Mohammed, Davicioni Elai, Erho Nicholas, Yousefi Kasra, Zhao Shuang, Haddad Zaid, Den Robert B, Dicker Adam P, Trock Bruce J, DeMarzo Angelo M, Ross Ashley E, Schaeffer Edward M, Klein Eric A, Magi-Galluzzi Cristina, Karnes R Jeffrey, Jenkins Robert B, Feng Felix Y

Abstract excerpt

BACKGROUND: Prostate cancer (PCa) molecular subtypes have been defined by essentially mutually exclusive events, including ETS gene fusions (most commonly involving ERG) and SPINK1 overexpression. Clinical assessment may aid in disease stratification, complementing available prognostic tests. OBJECTIVE: To determine the analytical validity and clinicopatholgic associations of microarray-based molecular subtyping....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 25964175
DOI: 10.1016/j.eururo.2015.04.033
PMCID: PMC4562381

Genes

ERG
SPINK1

Provenance

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