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Article

Somatic molecular subtyping of prostate tumors from HOXB13 G84E carriers.

Oncotarget - 4 Apr 2017

Lotan Tamara L, Torres Alba, Zhang Miao, Tosoian Jeffrey J, Guedes Liana B, Fedor Helen, Hicks Jessica, Ewing Charles M, Isaacs Sarah D, Johng Dorhyun, De Marzo Angelo M, Isaacs William B

Abstract excerpt

A recurrent germline mutation (G84E) in the HOXB13 gene is associated with early onset and family history-positive prostate cancer in patients of European descent, occurring in up to 5% of prostate cancer families. To date, the molecular features of prostate tumors occurring in HOXB13 G84E carriers have not been studied in a large cohort of patients. We identified 101 heterozygous carriers of G84E who underwent...

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Source

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Identifiers

PMID: 28186998
DOI: 10.18632/oncotarget.15196
PMCID: PMC5410261

Genes

HOXB13
ERG
PTEN
ETV1
SPINK1

Variants

Provenance

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