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Article

Solution structure and DNA-binding properties of the winged helix domain of the meiotic recombination HOP2 protein.

The Journal of biological chemistry - 23 May 2014

Moktan Hem, Guiraldelli Michel F, Eyster Craig A, Zhao Weixing, Lee Chih-Ying, Mather Timothy, Camerini-Otero R Daniel, Sung Patrick, Zhou Donghua H, Pezza Roberto J

Abstract excerpt

The HOP2 protein is required for efficient double-strand break repair which ensures the proper synapsis of homologous chromosomes and normal meiotic progression. We previously showed that in vitro HOP2 shows two distinctive activities: when it is incorporated into a HOP2-MND1 heterodimer, it stimulates DMC1 and RAD51 recombination activities, and the purified HOP2 alone is proficient in promoting strand invasion....

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Source

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Identifiers

PMID: 24711446
DOI: 10.1074/jbc.M114.548180
PMCID: PMC4031524

Genes

DMC1
MND1
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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