Article
The Mnd1 protein forms a complex with hop2 to promote homologous chromosome pairing and meiotic double-strand break repair.
Molecular and cellular biology - 1 May 2002
Tsubouchi Hideo, Roeder G Shirleen
Abstract excerpt
The hop2 mutant of Saccharomyces cerevisiae arrests in meiosis with extensive synaptonemal complex (SC) formation between nonhomologous chromosomes. A screen for multicopy suppressors of a hop2-ts allele identified the MND1 gene. The mnd1-null mutant arrests in meiotic prophase, with most double-strand breaks (DSBs) unrepaired. A low level of mature recombinants is produced, and the Rad51 protein accumulates at...
Topics
- Alleles
- Amino Acid Sequence
- Animals
- Base Sequence
- Chromosomal Proteins, Non-Histone
- Chromosome Pairing
- Chromosomes, Fungal
- Cloning, Molecular
- DNA Damage
- DNA Repair
- DNA-Binding Proteins
- Fungal Proteins
- Meiosis
- Molecular Sequence Data