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Article

Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.

Molecular and cellular biology - 1 Jun 2014

Forristal Chantal, Henley Shauna A, MacDonald James I, Bush Jason R, Ort Carley, Passos Daniel T, Talluri Srikanth, Ishak Charles A, Thwaites Michael J, Norley Chris J, Litovchick Larisa, DeCaprio James A, DiMattia Gabriel, Holdsworth David W, Beier Frank, Dick Frederick A

Abstract excerpt

Mammalian DREAM is a conserved protein complex that functions in cellular quiescence. DREAM contains an E2F, a retinoblastoma (RB)-family protein, and the MuvB core (LIN9, LIN37, LIN52, LIN54, and RBBP4). In mammals, MuvB can alternatively bind to BMYB to form a complex that promotes mitotic gene expression. Because BMYB-MuvB is essential for proliferation, loss-of-function approaches to study MuvB have generated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24710275
DOI: 10.1128/MCB.01523-13
PMCID: PMC4054284

Genes

LIN52
LIN37
LIN54
LIN9
RBBP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Loss of the mammalian DREAM complex deregulates chondrocyte proliferation.PMID 24710275Read ↗

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Evolutionarily conserved multisubunit RBL2/p130 and E2F4 protein complex represses human cell cycle-dependent genes in quiescence.Semantic proximity Read ↗

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Loss of pRB and p107 disrupts cartilage development and promotes enchondroma formation.Semantic proximity Read ↗

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An E2F binding-deficient Rb1 protein partially rescues developmental defects associated with Rb1 nullizygosity.Semantic proximity Read ↗

RBP-J (Rbpsuh) is essential to maintain muscle progenitor cells and to generate satellite cells.Semantic proximity Read ↗

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