Article

The cell cycle gene regulatory DREAM complex is disrupted by high expression of oncogenic B-Myb

2017-10-06

Abstract excerpt

The oncogene MYBL2 (encoding B-Myb) is a poor prognostic biomarker in many cancers. B-Myb interacts with the MuvB core of five proteins (LIN9, LIN37, LIN52, LIN53/RBBP4, and LIN54) to form the MMB (Myb-MuvB) complex and promotes expression of late cell cycle genes necessary for progression through mitosis. Both MYBL2 amplification and over-expression are associated with deregulation of the cell cycle and increas...

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Literature Corpus work: c6723c14-acf4-5325-b618-1fd90df04c26
DOI: 10.1101/199539

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