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Article

Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.

Cell cycle (Georgetown, Tex.) - 1 Oct 2004

Franchitto Annapaola, Pichierri Pietro

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disease that predisposes individuals to a wide range of cancers. The gene mutated in WS, WRN, encodes a member of the RecQ family of DNA helicases. The precise DNA metabolic processes in which WRN participates remain to be elucidated. However, it has...

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Source

Identifiers

PMID: 15467456
DOI: 10.4161/cc.3.10.1185

Genes

WRN
MRE11
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15467456-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.PMID 15467456Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathwaySemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrestSemantic proximity Read ↗

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.Semantic proximity Read ↗

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.Semantic proximity Read ↗

Telomere dysfunction as a cause of genomic instability in Werner syndromeSemantic proximity Read ↗

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WRN as a Novel Target of Synthetic Lethality: Current Advances and Future PerspectivesSemantic proximity Read ↗

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