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Article

Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.

Cell cycle (Georgetown, Tex.) - 1 Oct 2004

Franchitto Annapaola, Pichierri Pietro

Abstract excerpt

Werner syndrome (WS) is an autosomal recessive disease that predisposes individuals to a wide range of cancers. The gene mutated in WS, WRN, encodes a member of the RecQ family of DNA helicases. The precise DNA metabolic processes in which WRN participates remain to be elucidated. However, it has been proposed that WRN might play an important role in the maintenance of genetic stability during DNA replication,...

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Source

Identifiers

PMID: 15467456
DOI: 10.4161/cc.3.10.1185

Genes

WRN
MRE11
PCNA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Werner syndrome protein and the MRE11 complex are involved in a common pathway of replication fork recovery.PMID 15467456Read ↗

Werner syndrome protein: functions in the response to DNA damage and replication stress in S-phase.Semantic proximity Read ↗

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrestSemantic proximity Read ↗

Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathwaySemantic proximity Read ↗

Response to Replication Stress and Maintenance of Genome Stability by WRN, the Werner Syndrome ProteinSemantic proximity Read ↗

Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrestSemantic proximity Read ↗

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.Semantic proximity Read ↗

Werner syndrome: molecular insights into the relationships between defective DNA metabolism, genomic instability, cancer and aging.Semantic proximity Read ↗

Telomere dysfunction as a cause of genomic instability in Werner syndromeSemantic proximity Read ↗

WRN regulates pathway choice between classical and alternative non-homologous end joiningSemantic proximity Read ↗

WRN as a Novel Target of Synthetic Lethality: Current Advances and Future PerspectivesSemantic proximity Read ↗

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The Werner syndrome RECQ helicase as a therapeutic target: new insights.Semantic proximity Read ↗

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