PDF and cAMP enhance PER stability in Drosophila clock neurons.

doi:10.1073/pnas.1402562111

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Article

PDF and cAMP enhance PER stability in Drosophila clock neurons.

Proceedings of the National Academy of Sciences of the United States of America - 1 Apr 2014

Li Yue, Guo Fang, Shen James, Rosbash Michael

Abstract excerpt

The neuropeptide PDF is important for Drosophila circadian rhythms: pdf(01) (pdf-null) animals are mostly arrhythmic or short period in constant darkness and have an advanced activity peak in light-dark conditions. PDF contributes to the amplitude, synchrony, as well as the pace of circadian rhythms within clock neurons. PDF is known to increase cAMP levels in PDR receptor (PDFR)-containing neurons. However,...

Topics

Animals
Biological Clocks
Brain
Circadian Rhythm
Cyclic AMP
Cyclic AMP-Dependent Protein Kinases
Drosophila Proteins
Drosophila melanogaster
Enzyme Activation
Light
Neurons
Neuropeptides
Period Circadian Proteins
Phenotype
Protein Stability
Proteolysis
Up-Regulation

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Identifiers

PMID: 24707054
DOI: 10.1073/pnas.1402562111
PMCID: PMC3977231

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