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Article

The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.

PLoS biology - 1 Jul 2009

Lear Bridget C, Zhang Luoying, Allada Ravi

Abstract excerpt

Discrete clusters of circadian clock neurons temporally organize daily behaviors such as sleep and wake. In Drosophila, a network of just 150 neurons drives two peaks of timed activity in the morning and evening. A subset of these neurons expresses the neuropeptide pigment dispersing factor (PDF), which is important for promoting morning behavior as well as maintaining robust free-running rhythmicity in constant...

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Share to Behavior, Animal
Share to Circadian Rhythm
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Motor Activity

Share to Neuropeptides

Share to Period Circadian Proteins

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Share to Receptors, G-Protein-Coupled

Source

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Identifiers

PMID: 19621061
DOI: 10.1371/journal.pbio.1000154
PMCID: PMC2702683

Genes

PDF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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