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Article

PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors.

Neuron - 20 Oct 2005

Mertens Inge, Vandingenen Anick, Johnson Erik C, Shafer Orie T, Li W, Trigg J S, De Loof Arnold, Schoofs Liliane, Taghert Paul H

Abstract excerpt

The neuropeptide Pigment-Dispersing Factor (PDF) is a principle transmitter regulating circadian locomotor rhythms in Drosophila. We have identified a Class II (secretin-related) G protein-coupled receptor (GPCR) that is specifically responsive to PDF and also to calcitonin-like peptides and to PACAP. In response to PDF, the PDF receptor (PDFR) elevates cAMP levels when expressed in HEK293 cells. As predicted by...

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Identifiers

PMID: 16242402
DOI: 10.1016/j.neuron.2005.09.009

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PDF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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PDF receptor signaling in Drosophila contributes to both circadian and geotactic behaviors.PMID 16242402Read ↗

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PDF receptor signaling in Caenorhabditis elegans modulates locomotion and egg-laying.Semantic proximity Read ↗

The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila.Semantic proximity Read ↗

PDF receptor expression reveals direct interactions between circadian oscillators in Drosophila.Semantic proximity Read ↗

Regulation of PDF receptor signaling controlling daily locomotor rhythms in <i>Drosophila</i>Semantic proximity Read ↗

The neuropeptide PDF acts directly on evening pacemaker neurons to regulate multiple features of circadian behavior.Semantic proximity Read ↗

Drosophila GPCR Han is a receptor for the circadian clock neuropeptide PDF.Semantic proximity Read ↗

PDF and cAMP enhance PER stability in Drosophila clock neurons.Semantic proximity Read ↗

PDFR and CRY signaling converge in a subset of clock neurons to modulate the amplitude and phase of circadian behavior in Drosophila.Semantic proximity Read ↗

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