Article
The circadian neuropeptide PDF signals preferentially through a specific adenylate cyclase isoform AC3 in M pacemakers of Drosophila.
PLoS biology - 1 Jan 2012
Duvall Laura B, Taghert Paul H
Abstract excerpt
The neuropeptide Pigment Dispersing Factor (PDF) is essential for normal circadian function in Drosophila. It synchronizes the phases of M pacemakers, while in E pacemakers it decelerates their cycling and supports their amplitude. The PDF receptor (PDF-R) is present in both M and subsets of E cells. Activation of PDF-R stimulates cAMP increases in vitro and in M cells in vivo. The present study asks: What is the...
Topics
- Adenylyl Cyclases
- Animals
- Animals, Genetically Modified
- Biological Clocks
- Brain
- Cells, Cultured
- Circadian Rhythm
- Drosophila
- Drosophila Proteins
- Neurons
- Neuropeptides
- Phenotype
- Protein Isoforms
- RNA Interference
- Receptors, G-Protein-Coupled
- Signal Transduction