Article
Mechanisms of mutagenesis: DNA replication in the presence of DNA damage.
Mutation research. Reviews in mutation research - 1 Jan 2000
Liu Binyan, Xue Qizhen, Tang Yong, Cao Jia, Guengerich F Peter, Zhang Huidong
Abstract excerpt
Environmental mutagens cause DNA damage that disturbs replication and produces mutations, leading to cancer and other diseases. We discuss mechanisms of mutagenesis resulting from DNA damage, from the level of DNA replication by a single polymerase to the complex DNA replisome of some typical model organisms (including bacteriophage T7, T4, Sulfolobus solfataricus, Escherichia coli, yeast and human). For a single...
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