Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Patterns of chromosomal fragmentation due to uracil-DNA incorporation reveal a novel mechanism of replication-dependent double-stranded breaks.

Molecular microbiology - 1 Apr 2008

Kouzminova Elena A, Kuzminov Andrei

Abstract excerpt

There is growing evidence that spontaneous chromosomal fragmentation, one of the main contributors to genetic instability, is intimately linked to DNA replication. In particular, we proposed before that uracil incorporation in DNA triggers chromosomal fragmentation due to replication fork collapse at uracil-excision intermediates. We tested predictions of this model at the chromosomal level in the dut mutants of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosome Breakage
Share to Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to DNA Breaks, Double-Stranded

Share to DNA Damage

Share to DNA Replication

Share to Genes, Bacterial

Share to Uracil

Source

Identifiers

PMID: 18312272
DOI: 10.1111/j.1365-2958.2008.06149.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Patterns of chromosomal fragmentation due to uracil-DNA incorporation reveal a novel mechanism of replication-dependent double-stranded breaks.PMID 18312272Read ↗

Thymine-starvation-induced chromosomal fragmentation is not required for thymineless death in Escherichia coli.Semantic proximity Read ↗

Chromosomal fragmentation in dUTPase-deficient mutants of Escherichia coli and its recombinational repair.Semantic proximity Read ↗

Disintegration of nascent replication bubbles during thymine starvation triggers RecA- and RecBCD-dependent replication origin destruction.Semantic proximity Read ↗

Stalled replication fork repair and misrepair during thymineless death in Escherichia coli.Semantic proximity Read ↗

Chromosome demise in the wake of ligase-deficient replication.Semantic proximity Read ↗

Chronology in lesion tolerance gives priority to genetic variability.Semantic proximity Read ↗

UV-induced DNA damage disrupts the coordination between replication initiation, elongation and completion.Semantic proximity Read ↗

Replication fork inhibition in seqA mutants of Escherichia coli triggers replication fork breakage.Semantic proximity Read ↗

RdgB acts to avoid chromosome fragmentation in Escherichia coli.Semantic proximity Read ↗

RecA-dependent mutants in Escherichia coli reveal strategies to avoid chromosomal fragmentation.Semantic proximity Read ↗

Encoded errors: mutations and rearrangements mediated by misalignment at repetitive DNA sequences.Semantic proximity Read ↗

Z-DNA-forming sequences generate large-scale deletions in mammalian cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.