Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nondisruptive p53 mutations are associated with shorter survival in patients with advanced non-small cell lung cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2014

Molina-Vila Miguel A, Bertran-Alamillo Jordi, Gascó Amaya, Mayo-de-las-Casas Clara, Sánchez-Ronco María, Pujantell-Pastor Laia, Bonanno Laura, Favaretto Adolfo G, Cardona Andrés F, Vergnenègre Alain, Majem Margarita, Massuti Bartomeu, Morán Teresa, Carcereny Enric, Viteri Santiago, Rosell Rafael

Abstract excerpt

PURPOSE: TP53 mutations in early-stage non-small cell lung cancer (NSCLC) may be associated with worse survival but their prognostic role in advanced NSCLC is controversial. In addition, it remains unclear whether mutated patients represent a clinically homogeneous group. EXPERIMENTAL DESIGN: We retrospectively examined TP53 mutations and outcome in a training cohort of 318 patients with stage IIIB-IV NSCLC: 125...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Carcinoma, Non-Small-Cell Lung

Share to Disease-Free Survival

Share to ErbB Receptors

Share to Neoplasm Staging

Share to Prognosis

Share to Tumor Suppressor Protein p53

Source

Identifiers

PMID: 24696321
DOI: 10.1158/1078-0432.CCR-13-2391

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nondisruptive p53 mutations are associated with shorter survival in patients with advanced non-small cell lung cancer.PMID 24696321Read ↗

Mutations of the p53 gene as a predictor of poor prognosis in patients with non-small-cell lung cancer.Semantic proximity Read ↗

Concomitant TP53 mutations with response to crizotinib treatment in patients with ALK‐rearranged non‐small‐cell lung cancerSemantic proximity Read ↗

Predictive and Prognostic Potential of TP53 in Patients With Advanced Non-Small-Cell Lung Cancer Treated With EGFR-TKI: Analysis of a Phase III Randomized Clinical Trial (CTONG 0901).Semantic proximity Read ↗

Mutations in the p53 gene are frequent in primary, resected non-small cell lung cancer. Lung Cancer Study Group.Semantic proximity Read ↗

p53 mutations and survival in stage I non-small-cell lung cancer: results of a prospective study.Semantic proximity Read ↗

TP53 mutations and survival in squamous-cell carcinoma of the head and neck.Semantic proximity Read ↗

Significance of TP53 mutations as predictive markers of adjuvant cisplatin-based chemotherapy in completely resected non-small-cell lung cancer.Semantic proximity Read ↗

p53 mutations in defined structural and functional domains are related to poor clinical outcome in non-small cell lung cancer patients.Semantic proximity Read ↗

Correlation between the status of the p53 gene and survival in patients with stage I non-small cell lung carcinoma.Semantic proximity Read ↗

p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer.Semantic proximity Read ↗

p53 gene mutations are associated with shortened survival in patients with advanced non-small cell lung cancer: an analysis of medically managed patients.Semantic proximity Read ↗

Aberrations of the p53 tumor suppressor gene in human non-small cell carcinomas of the lung.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.