Article
p53 exon 5 mutations as a prognostic indicator of shortened survival in non-small-cell lung cancer.
British journal of cancer - 1 Jan 1997
Vega F J, Iniesta P, Caldés T, Sanchez A, López J A, de Juan C, Diaz-Rubio E, Torres A, Balibrea J L, Benito M
Abstract excerpt
Inactivation of the tumour-suppressor gene p53 has been described as one of the most common molecular changes found in lung tumours. Our purpose was to study the prognostic value of p53 alterations and to determine whether some specific mutation type in the p53 gene could be associated with poor...
Topics
- Carcinoma, Non-Small-Cell Lung
- Exons
- Female
- Genes, p53
- Humans
- Immunohistochemistry
- Lung Neoplasms
- Male
- Middle Aged
- Mutation
- Prognosis
- Time Factors
- Tumor Suppressor Protein p53