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Article

p53 mutations in defined structural and functional domains are related to poor clinical outcome in non-small cell lung cancer patients.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Mar 2000

Skaug V, Ryberg D, Kure E H, Arab M O, Stangeland L, Myking A O, Haugen A

Abstract excerpt

The prognostic value of p53 status in non-small cell lung cancer has been investigated in 148 patients with clinical stage I-IIIB disease. Tumor tissues were examined for mutations in exons 4-9, with emphasis on defined structural and functional domains. Eighty-four mutations were detected in 83 (54%) of the patients. Eighty-eight percent of the mutations were within exons 5-8, and 12% of the mutations were...

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Share to Carcinoma, Non-Small-Cell Lung
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 10741731

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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