Article
Deep sequencing of prostaglandin-endoperoxide synthase (PTGE) genes reveals genetic susceptibility for cross-reactive hypersensitivity to NSAID.
British journal of pharmacology - 1 Mar 2021
García-Martín Elena, García-Menaya Jesús M, Esguevillas Gara, Cornejo-García José A, Doña Inmaculada, Jurado-Escobar Raquel, Torres María J, Blanca-López Natalia, Canto Gabriela, Blanca Miguel, Laguna José J, Bartra Joan, Rosado Ana, Fernández Javier, Cordobés Concepción, Agúndez José A G
Abstract excerpt
BACKGROUND AND PURPOSE: Cross-reactive hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) is a relatively common adverse drug event caused by two or more chemically unrelated drugs and that is attributed to inhibition of the COX activity, particularly COX-1. Several studies investigated variations in the genes coding for COX enzymes as potential risk factors. However, these studies only...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.