Article
A mutated anti-CA19-9 scFv-Fc for positron emission tomography of human pancreatic cancer xenografts.
Molecular imaging and biology - 1 Oct 2014
Rochefort Matthew M, Girgis Mark D, Knowles Scott M, Ankeny Jacob S, Salazar Felix, Wu Anna M, Tomlinson James S
Abstract excerpt
PURPOSE: Intact antibodies have a long serum persistence resulting in high background signal that inhibits their direct translation as imaging agents. Engineering of antibody fragments through the introduction of mutations in the fragment crystallizable (Fc) region can dramatically reduce serum persistence. We sought to develop a Fc-mutated, anti-CA19-9 antibody fragment (anti-CA 19-9 scFv-Fc H310A) to provide...
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