Article
An affinity matured minibody for PET imaging of prostate stem cell antigen (PSCA)-expressing tumors.
European journal of nuclear medicine and molecular imaging - 1 Aug 2010
Lepin Eric J, Leyton Jeffrey V, Zhou Yu, Olafsen Tove, Salazar Felix B, McCabe Katelyn E, Hahm Scott, Marks James D, Reiter Robert E, Wu Anna M
Abstract excerpt
PURPOSE: Prostate stem cell antigen (PSCA), a cell surface glycoprotein expressed in normal human prostate and bladder, is over-expressed in the majority of localized prostate cancer and most bone metastases. We have previously shown that the hu1G8 minibody, a humanized anti-PSCA antibody fragmen...
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