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Article

Fully human antibody VH domains to generate mono and bispecific CAR to target solid tumors.

Journal for immunotherapy of cancer - 1 Apr 2021

Wang Guanmeng, Zhou Xin, Fucà Giovanni, Dukhovlinova Elena, Shou Peishun, Li Hongxia, Johnston Colette, Mcguinness Brian, Dotti Gianpietro, Du Hongwei

Abstract excerpt

BACKGROUND: Chimeric antigen receptor (CAR) T cells are effective in B-cell malignancies. However, heterogeneous antigen expression and antigen loss remain important limitations of targeted immunotherapy in solid tumors. Therefore, targeting multiple tumor-associated antigens simultaneously is expected to improve the outcome of CAR-T cell therapies. Due to the instability of single-chain variable fragments, it...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Cytotoxicity, Immunologic

Share to Immunoglobulin Variable Region

Share to Immunotherapy, Adoptive

Share to Mice, Inbred NOD

Share to Receptors, Chimeric Antigen

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Source

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Identifiers

PMID: 33795386
DOI: 10.1136/jitc-2020-002173
PMCID: PMC8021891

Genes

MSLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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