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Humanized Radioiodinated Minibody For Imaging of Prostate Stem Cell Antigen–Expressing Tumors

14 Nov 2008

Abstract excerpt

PURPOSE: Prostate stem cell antigen (PSCA) is a cell surface glycoprotein that is overexpressed in prostate cancer, including hormone refractory disease. Previous preclinical studies showed the intact anti-PSCA antibodies, 1G8 and hu1G8, localized specifically to PSCA-expressing xenografts. Optimal micro positron emission tomography (microPET) imaging using hu1G8, however, required a delay of 168 hours...

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PMID: 19010866
DOI: 10.1158/1078-0432.ccr-07-5093

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