Article
Tacrolimus concentrations in relation to CYP3A and ABCB1 polymorphisms among solid organ transplant recipients in Korea.
Transplantation - 27 Apr 2009
Jun Kyung Ran, Lee Woochang, Jang Mi Sook, Chun Sail, Song Gi-Won, Park Kwan Tae, Lee Sung Gyu, Han Duck Jong, Kang Changwon, Cho Dae-Yeon, Kim Jin Q, Min Won-Ki
Abstract excerpt
BACKGROUND: Cytochrome P450 3A (CYP3A) and the drug transporter P-glycoprotein (P-gp) affect the bioavailability of tacrolimus, the most commonly used immunosuppressive agent in organ transplant recipients. We have determined the genotypic frequencies of the CYP3A and ATP-binding cassette sub-family B member 1 (ABCB1) genes, which encode the CYP3A and P-gp proteins, respectively, in Korean organ transplant...
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