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Article

CYP3A4∗18B and CYP3A5∗3 polymorphisms contribute to pharmacokinetic variability of cyclosporine among healthy Chinese subjects.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences - 30 Aug 2015

Tao Xing-ru, Xia Xiu-yuan, Zhang Jing, Tong Lian-ying, Zhang Wei, Zhou Xin, Liu Zhi-Hong, Song Hong-tao

Abstract excerpt

AIM: Cyclosporine is an immunosuppressant drug used to prevent allograft rejection. It is metabolized by CYP3A4 and CYP3A5, has a narrow therapeutic index, and variable pharmacokinetics. Here, we investigated whether CYP3A5∗3 and CYP3A4∗18B polymorphisms contribute to inter-individual pharmacokinetic variability in healthy subjects. PATIENTS AND METHODS: Fifty-six healthy Chinese subjects were enrolled in the...

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PMID: 25976223
DOI: 10.1016/j.ejps.2015.05.011

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