Article
Effects of the CYP3A5*3 variant on cyclosporine exposure and acute rejection rate in renal transplant patients: a meta-analysis.
Pharmacogenetics and genomics - 1 Sept 2010
Tang Hui-Lin, Ma Lu-Lin, Xie Hong-Guang, Zhang Ting, Hu Yong-Fang
Abstract excerpt
BACKGROUND: Whether the loss-of-function allele CYP3A5*3 variant is associated with significantly impaired metabolism of cyclosporine A (CsA) in transplant patients is still controversial because of the lack of prospective, large-scale clinical studies performed among diversely ethnic populations. OBJECTIVES: This meta-analysis was designed to determine whether the CYP3A5*3 variant could affect CsA blood...
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