Article
KCNE2 modulation of Kv4.3 current and its potential role in fatal rhythm disorders.
Heart rhythm - 1 Jan 2010
Wu Jie, Shimizu Wataru, Ding Wei-Guang, Ohno Seiko, Toyoda Futoshi, Itoh Hideki, Zang Wei-Jin, Miyamoto Yoshihiro, Kamakura Shiro, Matsuura Hiroshi, Nademanee Koonlawee, Brugada Josep, Brugada Pedro, Brugada Ramon, Vatta Matteo, Towbin Jeffrey A, Antzelevitch Charles, Horie Minoru
Abstract excerpt
BACKGROUND: The transient outward current I(to) is of critical importance in regulating myocardial electrical properties during the very early phase of the action potential. The auxiliary beta subunit KCNE2 recently was shown to modulate I(to). OBJECTIVE: The purpose of this study was to examine...
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