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Article

PAPNC, a novel method to calculate nucleotide diversity from large scale next generation sequencing data.

Journal of virological methods - 1 Jul 2014

Shao Wei, Kearney Mary F, Boltz Valerie F, Spindler Jonathan E, Mellors John W, Maldarelli Frank, Coffin John M

Abstract excerpt

Estimating viral diversity in infected patients can provide insight into pathogen evolution and emergence of drug resistance. With the widespread adoption of deep sequencing, it is important to develop tools to accurately calculate population diversity from very large datasets. Current methods for estimating diversity that are based on multiple alignments are not practical to apply to such data. In this study,...

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Identifiers

PMID: 24681054
DOI: 10.1016/j.jviromet.2014.03.008
PMCID: PMC4104926

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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