Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.

Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Mar 2015

Nelson Chase W, Hughes Austin L

Abstract excerpt

Next-generation sequencing (NGS) technology offers new opportunities for understanding the evolution and dynamics of viral populations within individual hosts over the course of infection. We review simple methods for estimating synonymous and nonsynonymous nucleotide diversity in viral genes from NGS data without the need for inferring linkage. We discuss the potential usefulness of these data for addressing...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Virology
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics, Population

Share to Genome, Viral

Share to Haplorhini

Share to High-Throughput Nucleotide Sequencing

Share to Sequence Analysis, DNA

Share to Sequence Analysis, RNA

Source

Open in PubMed Open full text

Identifiers

PMID: 25481279
DOI: 10.1016/j.meegid.2014.11.026
PMCID: PMC4316684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Within-host nucleotide diversity of virus populations: insights from next-generation sequencing.PMID 25481279Read ↗

Ultra-deep sequencing for the analysis of viral populations.Semantic proximity Read ↗

Epidemiological data analysis of viral quasispecies in the next-generation sequencing eraSemantic proximity Read ↗

Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing dataSemantic proximity Read ↗

Viral genome sequencing methods: benefits and pitfalls of current approachesSemantic proximity Read ↗

Estimating Fitness of Viral Quasispecies from Next-Generation Sequencing Data.Semantic proximity Read ↗

Mutational and fitness landscapes of an RNA virus revealed through population sequencing.Semantic proximity Read ↗

Stochastic processes dominate the within and between host evolution of influenza virusSemantic proximity Read ↗

Complexities of Viral Mutation Rates.Semantic proximity Read ↗

Understanding the complex evolution of rapidly mutating viruses with deep sequencing: Beyond the analysis of viral diversity.Semantic proximity Read ↗

The population genetics and evolutionary epidemiology of RNA viruses.Semantic proximity Read ↗

Genetic Drift, Purifying Selection and Vector Genotype Shape Dengue Virus Intra-host Genetic Diversity in Mosquitoes.Semantic proximity Read ↗

Virus-derived variation in diverse human genomesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.