Article
Higher HIV-1 genetic diversity is associated with AIDS and neuropsychological impairment.
Virology - 25 Nov 2012
Hightower George K, Wong Joseph K, Letendre Scott L, Umlauf Anya A, Ellis Ronald J, Ignacio Caroline C, Heaton Robert K, Collier Ann C, Marra Christina M, Clifford David B, Gelman Benjamin B, McArthur Justin C, Morgello Susan, Simpson David M, McCutchan J A, Grant Igor, Little Susan J, Richman Douglas D, Kosakovsky Pond Sergei L, Smith Davey M
Abstract excerpt
Standard methods used to estimate HIV-1 population diversity are often resource intensive (e.g., single genome amplification, clonal amplification and pyrosequencing) and not well suited for large study cohorts. Additional approaches are needed to address the relationships between intraindividual HIV-1 genetic diversity and 2 disease. With a small cohort of individuals, we validated three methods for measuring...
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