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Article

hKChIP2 is a functional modifier of hKv4.3 potassium channels Cloning and expression of a short hKChIP2 splice variant

1 Nov 2001

Abstract excerpt

OBJECTIVE: The Ca(2+) independent transient outward K(+) current (I(to1)) in the heart is responsible for the initial phase of repolarization. The hKv4.3 K(+) channel alpha-subunit contributes to the I(to1) current in many regions of the human heart. Consistently, downregulation of hKv4.3 transcripts in heart failure and atrial fibrillation is linked to reduction in I(to1) conductance. The recently cloned KChIP...

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Share to Cardiac electrophysiology and arrhythmias
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PMID: 11684073
DOI: 10.1016/s0008-6363(01)00374-1

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