Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of Pyk2 in cardiac arrhythmogenesis.

American journal of physiology. Heart and circulatory physiology - 1 Sept 2011

Lang Di, Glukhov Alexey V, Efimova Tatiana, Efimov Igor R

Abstract excerpt

Proline-rich tyrosine kinase 2 (Pyk2) is a nonreceptor protein kinase regulated by intracellular Ca(2+), CaMK, and PKC and can be activated by different stress signals involved in heart failure. However, Pyk2 has not been investigated in the human heart, and the functional role of Pyk2 signaling at the whole heart level has not been elucidated. We hypothesize that Ca(2+)-dependent activation of Pyk2 is involved...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Heart Conduction System
Share to Perfusion
Share to Focal Adhesion Kinase 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Acetylcholine

Share to Autonomic Nervous System

Share to Cardiac Pacing, Artificial

Share to Sarcoplasmic Reticulum Calcium-Transporting ATPases

Share to Sodium-Calcium Exchanger

Source

Identifiers

PMID: 21666110
DOI: 10.1152/ajpheart.00241.2011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of Pyk2 in cardiac arrhythmogenesis.PMID 21666110Read ↗

Plakophilin-2 Haploinsufficiency Causes Calcium Handling Deficits and Modulates the Cardiac Response Towards StressSemantic proximity Read ↗

PKN2 deficiency leads both to prenatal ‘congenital’ cardiomyopathy and defective angiotensin II stress responsesSemantic proximity Read ↗

A defect in the Kv channel-interacting protein 2 (KChIP2) gene leads to a complete loss of I(to) and confers susceptibility to ventricular tachycardia.Semantic proximity Read ↗

Loss of K+ currents in heart failure is accentuated in KChIP2 deficient mice.Semantic proximity Read ↗

CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Semantic proximity Read ↗

Molecular biology of background K channels: insights from K(2P) knockout mice.Semantic proximity Read ↗

Gene-trapped mouse embryonic stem cell-derived cardiac myocytes and human genetics implicate AKAP10 in heart rhythm regulation.Semantic proximity Read ↗

Ca(2+)-sensitive tyrosine kinase Pyk2/CAK beta-dependent signaling is essential for G-protein-coupled receptor agonist-induced hypertrophy.Semantic proximity Read ↗

Protein kinase C epsilon-dependent activation of proline-rich tyrosine kinase 2 in neonatal rat ventricular myocytes.Semantic proximity Read ↗

Preservation of cardiac function by prolonged action potentials in mice deficient of KChIP2Semantic proximity Read ↗

Arrhythpy: An Automated Tool to Quantify and Classify Arrhythmias in Ca <sup>2+</sup> Transients of iPSC-CardiomyocytesSemantic proximity Read ↗

Pyk2 inhibition promotes contractile differentiation in arterial smooth muscle.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.