Article
Combinatorial analysis and algorithms for quasispecies reconstruction using next-generation sequencing.
BMC bioinformatics - 5 Jan 2011
Prosperi Mattia C F, Prosperi Luciano, Bruselles Alessandro, Abbate Isabella, Rozera Gabriella, Vincenti Donatella, Solmone Maria Carmela, Capobianchi Maria Rosaria, Ulivi Giovanni
Abstract excerpt
BACKGROUND: Next-generation sequencing (NGS) offers a unique opportunity for high-throughput genomics and has potential to replace Sanger sequencing in many fields, including de-novo sequencing, re-sequencing, meta-genomics, and characterisation of infectious pathogens, such as viral quasispecies. Although methodologies and software for whole genome assembly and genome variation analysis have been developed and...
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