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Article

Conversion of channelrhodopsin into a light-gated chloride channel.

Science (New York, N.Y.) - 25 Apr 2014

Wietek Jonas, Wiegert J Simon, Adeishvili Nona, Schneider Franziska, Watanabe Hiroshi, Tsunoda Satoshi P, Vogt Arend, Elstner Marcus, Oertner Thomas G, Hegemann Peter

Abstract excerpt

The field of optogenetics uses channelrhodopsins (ChRs) for light-induced neuronal activation. However, optimized tools for cellular inhibition at moderate light levels are lacking. We found that replacement of E90 in the central gate of ChR with positively charged residues produces chloride-cond...

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Identifiers

PMID: 24674867
DOI: 10.1126/science.1249375

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24674867-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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