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Article

The Expanding Family of Natural Anion Channelrhodopsins Reveals Large Variations in Kinetics, Conductance, and Spectral Sensitivity.

Scientific reports - 3 Mar 2017

Govorunova Elena G, Sineshchekov Oleg A, Rodarte Elsa M, Janz Roger, Morelle Olivier, Melkonian Michael, Wong Gane K-S, Spudich John L

Abstract excerpt

Natural anion channelrhodopsins (ACRs) discovered in the cryptophyte alga Guillardia theta generate large hyperpolarizing currents at membrane potentials above the Nernst equilibrium potential for Cl- and thus can be used as efficient inhibitory tools for optogenetics. We have identified and characterized new ACR homologs in different cryptophyte species, showing that all of them are anion-selective, and thus...

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Identifiers

PMID: 28256618
DOI: 10.1038/srep43358
PMCID: PMC5335703

Genes

ACR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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