Article
Crystal structure of the channelrhodopsin light-gated cation channel.
Nature - 22 Jan 2012
Kato Hideaki E, Zhang Feng, Yizhar Ofer, Ramakrishnan Charu, Nishizawa Tomohiro, Hirata Kunio, Ito Jumpei, Aita Yusuke, Tsukazaki Tomoya, Hayashi Shigehiko, Hegemann Peter, Maturana Andrés D, Ishitani Ryuichiro, Deisseroth Karl, Nureki Osamu
Abstract excerpt
Channelrhodopsins (ChRs) are light-gated cation channels derived from algae that have shown experimental utility in optogenetics; for example, neurons expressing ChRs can be optically controlled with high temporal precision within systems as complex as freely moving mammals. Although ChRs have been broadly applied to neuroscience research, little is known about the molecular mechanisms by which these unusual and...
Topics
- Animals
- Bacteriorhodopsins
- Binding Sites
- Cations
- Cattle
- Chlamydomonas reinhardtii
- Crystallography, X-Ray
- Ion Channel Gating
- Ion Channels
- Light