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Article

Modelling mutational landscapes of human cancers in vitro.

Scientific reports - 27 Mar 2014

Olivier Magali, Weninger Annette, Ardin Maude, Huskova Hana, Castells Xavier, Vallée Maxime P, McKay James, Nedelko Tatiana, Muehlbauer Karl-Rudolf, Marusawa Hiroyuki, Alexander John, Hazelwood Lee, Byrnes Graham, Hollstein Monica, Zavadil Jiri

Abstract excerpt

Experimental models that recapitulate mutational landscapes of human cancers are needed to decipher the rapidly expanding data on human somatic mutations. We demonstrate that mutation patterns in immortalised cell lines derived from primary murine embryonic fibroblasts (MEFs) exposed in vitro to carcinogens recapitulate key features of mutational signatures observed in human cancers. In experiments with several...

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Identifiers

PMID: 24670820
DOI: 10.1038/srep04482
PMCID: PMC5259794

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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