Article
Bovine exome sequence analysis and targeted SNP genotyping of recessive fertility defects BH1, HH2, and HH3 reveal a putative causative mutation in SMC2 for HH3.
PloS one - 1 Jan 2014
McClure Matthew C, Bickhart Derek, Null Dan, Vanraden Paul, Xu Lingyang, Wiggans George, Liu George, Schroeder Steve, Glasscock Jarret, Armstrong Jon, Cole John B, Van Tassell Curtis P, Sonstegard Tad S
Abstract excerpt
The recent discovery of bovine haplotypes with negative effects on fertility in the Brown Swiss, Holstein, and Jersey breeds has allowed producers to identify carrier animals using commercial single nucleotide polymorphism (SNP) genotyping assays. This study was devised to identify the causative mutations underlying defective bovine embryo development contained within three of these haplotypes (Brown Swiss...
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