Article
A large structural variant collection in Holstein cattle and associated database for variant discovery, characterization, and application.
BMC genomics - 30 Sept 2024
Grant Jason R, Herman Emily K, Barlow Lael D, Miglior Filippo, Schenkel Flavio S, Baes Christine F, Stothard Paul
Abstract excerpt
BACKGROUND: Structural variants (SVs) such as deletions, duplications, and insertions are known to contribute to phenotypic variation but remain challenging to identify and genotype. A more complete, accessible, and assessable collection of SVs will assist efforts to study SV function in cattle and to incorporate SV genotyping into animal evaluation. RESULTS: In this work we produced a large and deeply...
Topics
- Animals
- Cattle
- Polymorphism, Single Nucleotide
- Genotype
- Female
- Whole Genome Sequencing
- Male
- Genomic Structural Variation
- Databases, Genetic
- Phenotype
- Genome