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Article

Identification of a nonsense mutation in APAF1 that is likely causal for a decrease in reproductive efficiency in Holstein dairy cattle.

Journal of dairy science - 1 Aug 2016

Adams Heather A, Sonstegard Tad S, VanRaden Paul M, Null Daniel J, Van Tassell Curt P, Larkin Denis M, Lewin Harris A

Abstract excerpt

The HH1 haplotype on chromosome 5 is associated with a reduced conception rate and a deficit of homozygotes at the population level in Holstein cattle. The source HH1 haplotype was traced to the bull Pawnee Farm Arlinda Chief (Chief), who was born in 1962 and has sired more than 16,000 daughters. We identified a nonsense mutation in APAF1 (apoptotic protease activating factor 1;APAF1 p.Q579X) within HH1 using...

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Identifiers

PMID: 27289157
DOI: 10.3168/jds.2015-10517

Genes

APAF1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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