Article
Identifying pleiotropic variants and candidate genes for fertility and reproduction traits in Holstein cattle via association studies based on imputed whole-genome sequence genotypes.
BMC genomics - 28 Apr 2022
Chen Shi-Yi, Schenkel Flavio S, Melo Ana L P, Oliveira Hinayah R, Pedrosa Victor B, Araujo Andre C, Melka Melkaye G, Brito Luiz F
Abstract excerpt
BACKGROUND: Genetic progress for fertility and reproduction traits in dairy cattle has been limited due to the low heritability of most indicator traits. Moreover, most of the quantitative trait loci (QTL) and candidate genes associated with these traits remain unknown. In this study, we used 5.6 million imputed DNA sequence variants (single nucleotide polymorphisms, SNPs) for genome-wide association studies...
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