SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury

Abstract excerpt

Hepatic stellate cells (HSCs) are crucial for liver injury repair and cirrhosis. However, the mechanism of chemotactic recruitment of HSCs into injury loci is still largely unknown. Here, we demonstrate that serum amyloid A1 (SAA1) acts as a chemokine recruiting HSCs toward injury loci signaling via TLR2, a finding proven by gene manipulation studies in cell and mice models. The mechanistic investigations...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Drug-Induced Hepatotoxicity and Protection
• Share to Liver Disease Diagnosis and Treatment
• Share to Liver physiology and pathology